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Symbol
Name
ID 		Htra2
HtrA serine peptidase 2
MGI:1928676
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Secondary microcephaly
Hyposmia
Increased CSF lactate
Dysphagia
Spasticity
Ventriculomegaly
Hypoplasia of the corpus callosum
Cerebral atrophy
Bradykinesia
Clonus
Tremor
Depression
Anxiety
Panic attack
Hallucinations
Apathy
Reduced social reciprocity
Impulsivity
Agitation
Restless legs
Cognitive impairment
Dementia
Frontal lobe dementia
Short attention span
Insomnia
Hyperreflexia
Dyskinesia
Dystonia
Gait imbalance
Postural instability
Elevated brain lactate level by MRS
Seizure
Abnormal autonomic nervous system physiology
Disease(s) Associated with HTRA2
3-methylglutaconic aciduria type 8
Parkinson's disease

Mouse Phenotypes
nervous system phenotype
seizures
increased susceptibility to neuronal excitotoxicity
increased brain apoptosis
abnormal nervous system morphology
abnormal brain morphology
decreased brain weight
decreased brain size
abnormal basal ganglion morphology
loss of basal ganglia neurons
abnormal cerebellar granule cell morphology
abnormal astrocyte morphology
gliosis
motor neuron degeneration
abnormal spinal cord morphology
neurodegeneration
abnormal action potential
Availability Mouse Genotype
Htra2mnd2/Htra2mnd2
Htra2tm1.2Hohj/Htra2tm1.2Hohj
Htra2tm1Jdo/Htra2tm1Jdo
Htra2tm1.1Hohj/Htra2tm1.1Hohj
Tg(Nes-cre)1Kln/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory